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Camptothecin Chemical Name:
4(S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14
(4H,12H)-dione It is light yellow powder or light yellow crystalline powder. It is easy to deteriorate when it meets light. It is east to be moistened. It owns the nature of indirect in the solution of Chloroform and Methanol(8: 2).It slightly dissolve in Ethanol and Chloroform etc. It is hardly dissolve in water and easy dissolve in sparse alkaline solution.
(1) Molecular Formula: C20H16N2O4 (2) Molecular Weight: 348.36 (3) Melting Point: 258~260  (4) Compared to curls: +31~32o (5) Contents(HPLC): >98% (6) Loss of drying: <0.5% (7) Sulphated ash: <0.1% (8) Heavy Metal: <10ppm (9) As: <2ppm 3. Function and Purpose 1) It mainly been applied for cancer of Digestive System, for example cancers of the stomach, gullet, cardia, intestines and liver cancer etc. 2) It is also used in cancers of oral cavity, nake, face and head, bladder cancer and lung cancer etc. 4. Usage: Pharmaceuticals Intermediates. 5. Storage: Kept away from light 6. Package: according to customers' needs Camptothecin is a quinoline-based alkaloid found in the barks of the chinese camptotheca tree and the Asian nothapodytes tree. Camptotheca acuminate as the fruit and root of the Chinese dove tree with cold nature and bitter flavor. In "Chinese herds" which is described as "cancer-curable, calculus exploded, curing the cancer in stomach, rectum and cystic, also has the good effects for chronic granulocytic leukemia. The whole Chinese dove tree contains the alkaloid-Camptothecin.Anti-cancer is the major pharmacodynamic effect. The anti-cancer presented is ¦Á-hydroxyl-lactone ring. In the human-mouse test of l-165 reticulum cell sarcoma ars abdominal dropsy and viral leukemia, camptothecin may reduce the number of white blood cells, ease the splenomegaly, reduce abdominal dropsy and the number of the active tumor cells in which. |
